Albrecht Dürer (1471-1528) fits the definition of a Renaissance man (though German rather than Italian). He was a painter, an engraver, a printmaker, and a mathematician who wrote books on geometry and human proportions.
Of all of these, I have a special preferences for his woodblock prints and engravings because of the delicacy and intricacy of the fine lines. To make a woodcut the artist carves an image into the surface of a block of wood, gouging out the parts he wants to remain white and leaving the part to be printed level with the surface. The block is then covered with ink and applied to paper. It sounds as though this technique would be clumsy and that only large, bloblike images would show. But look at this woodcut of the Four Horsemen of the Apocalypse:
There are blacks, grays, whites, all shades of monochrome, and the fine detailing looks like it was drawn with very fine pen and ink. Incredible to realize that this was all cut out of wood.
Here are some more examples of Dürer woodcuts: